Rawia Mohamed: IDH wild type high grade glioma
Rawia Mohamed, Associate Professor in Anatomical Pathology, Khalifa University, shared a post on LinkedIn:
“I got this recent brain tumor from an adult in frontoparietal region using immunohistochemistry the IDH shows negative staining with lost ATRX stain . The features are of IDH wild type high grade glioma.
The molecular testing using NGS was done and it shows EGFR amplification and TERT mutation confirming this tumor belongs to IDH wild type GBM WHO grade 4.
The advent of next-generation sequencing (NGS) has brought significant advancements in the classification and treatment of various brain tumors, including IDH-wildtype grade 4 GBM According to the 2021 WHO classification, NGS plays a pivotal role in confirming this classification and guiding treatment decisions, ensuring more personalized and effective care.
In IDH-wildtype grade 4 GBM, NGS is crucial for detecting molecular markers like TERT promoter mutations, EGFR amplification, and +7/-10 chromosomal copy number alterations. The presence of any of these specific alterations supports a diagnosis of glioblastoma, which is important since these molecular features correlate with aggressive clinical behavior and poor prognosis. Without NGS, distinguishing between high-grade astrocytomas that may respond differently to treatment would be challenging, potentially leading to less targeted and less effective therapies.”
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