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Nicholas Hornstein: Aspirin can prevent colon cancer?
Nicholas Hornstein/X
Apr 15, 2025, 17:01

Nicholas Hornstein: Aspirin can prevent colon cancer?

Nicholas Hornstein, GI Medical Oncologist at Northwell Health, shared on X a reccent paper by Anna Martling et al. :

“Aspirin can prevent colon cancer?
ALASCCA was a mic drop presentation at GI-ASCO earlier this year, but hasn’t gotten the press it deserves.
Pop: 1100 Resected colorectal cancer patients with PI3k mutation
Intervention: 160mg Aspirin x 3 years
Outcome: DFS HR .61, TTR .49
PI3k mutations occur with ~ 35% prevalence. Are these outcomes worth performing genetic testing on all patients? Or maybe all resected CRC patients should get aspirin?
All I know is I now have a big bottle of aspirin in my clinic…”

Low-dose aspirin to reduce recurrence rate in colorectal cancer patients with PI3K pathway alterations: 3-year results from a randomized placebo-controlled trial.

Authors: Anna Martling, Johan Lindberg, Ida Hed Myrberg, Mef Nilbert, Markus Mayrhofer, Henrik Gronberg, and Bengt Glimelius

Nicholas Hornstein

#cancer patients Anna Martling cancer Colon cancer CRC Henrik Grönberg Ida Hed Myrberg Johan Lindberg Markus Mayrhofer Mef Nilbert OncoDaily Oncology
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