Biobank of Patient-Derived Organoids for Personalized Therapy in Breast Cancer – International Journal of Cancer
International Journal of Cancer posted the following on LinkedIn:
A biobank of breast cancer patient-derived organoids shows they match original tumors’ traits and drug responses, highlighting their potential in personalized therapy for breast cancer.
Heterogeneity in breast cancer contributes to variations in treatment effectiveness. Patient-derived organoids (PDOs) have emerged as promising models to predict individualized drug responses, though their applicability to breast cancer remains largely unexplored. Here, the authors established a biobank of breast cancer PDOs to evaluate their feasibility in predicting patient drug response. Experiments demonstrate that the PDOs accurately inherit the histologic and genetic characteristics of the breast tumors from which they are derived. Moreover, drug susceptibility in PDOs corresponded to clinical responses in matched patients.”
Authors: Huizi Wu, Weiwei Wang, Yinbin Zhang, Yinxi Chen, Changyou Shan, Jia Li, Yiwei Jia, Chaofan Li, Chong Du, Yifan Cai, Yu Zhang, Shuqun Zhang, Fei Wu.
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