Gustavo Viani/sbradioterapia.com.br
Apr 6, 2025, 14:30
Gustavo Viani: HDR vs LDR Boost in Prostate Cancer
Gustavo Viani, Professor of Radiation Oncology at Ribeirão Preto Medical School, shared an article by Juanita Crook, et al. on X:
“HDR vs LDR Boost in Prostate Cancer: Is One Better?
New RCT sheds light on long-term efficacy for unfavorable-risk prostate cancer
Objective
Compare HDR vs LDR brachytherapy boost + EBRT in terms of biochemical control
Methods
- 190 randomized: HDR (15 Gy pre-EBRT) vs LDR (110 Gy post-EBRT)
- All received pelvic EBRT (46 Gy/23 fx) via IMRT/VMAT or 3D-CRT
- 76% received ADT; median f/u 74 months
- PSA ≤0.2 ng/ml at 4y = cure
Key Results
- 4y PSA ≤0.2: HDR 81% | LDR 83%
- 8y bPFS: HDR 85% | LDR 84%
- OS/CSS similar
Takeway:
Both techniques offer durable efficacy. Use may depend on center expertise and factors.”
A Randomized Comparison of High Dose Rate and Low Dose Rate Prostate Brachytherapy Combined with External Beam Radiotherapy for Unfavourable Prostate Cancer: Efficacy Results after Median Follow-up 74 Months
Authors: Juanita Crook, et al.
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