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Francesco Massari: Are we sure that the Parpi are for all patients or just selected ones?
Francesco Massari
Feb 18, 2025, 12:22

Francesco Massari: Are we sure that the Parpi are for all patients or just selected ones?

Francesco Massari, Medical Oncologist focused on Genitourinary Cancer at The University Hospital of Bologna IRCCS, shared a post on X:

“Fantastic results by Talapro-2 trial about the combination talazoparib and enzalutamide in 1st line mCRPC.

But.. are we sure that the Parpi are for all patients or just selected ones?”

Quoting Tom Powles‘s post:

“TALAPR02 looks at Talazoparib/enza vs enza in 1st line CRPC.

It has significant OS in ITT HR=0.796. It’s current used in HRR deficient.

Subset analysis and wider data still supports the HRR biomarker OS (HRR deficient HR -0.54, HRR non-defficent/NA 0.87), but ITT OS is +ve.”\

Francesco Massari: Are we sure that the Parpi are for all patients or just selected ones?

cancer CRPC Enzalutamide fight against cancer Francesco Massari Genitourinary Cancer Global fight against cancer mCRPC MedOnc OncoDaily Oncology PARPi TALAPR02 TALAPRO-2 Talazoparib University Hospital of Bologna IRCCS
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