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Joe Chang: Optimal first-line treatment for EGFR-mutated mNSCLC
Joe Y. Chang/X
Mar 30, 2025, 16:56

Joe Chang: Optimal first-line treatment for EGFR-mutated mNSCLC

Joe Chang, Director of the Stereotactic Ablative Radiotherapy Program at MD Anderson Cancer Center, shared a post on X:

“Optimal first-line treatment for EGFR-mutated mNSCLC?

  1. Tagrisso alone for most patients.
  2. Tagrisso plus chemo for high-risk patients (brain/liver mets or large size)
  3. Amivantamab: Ab EGFR and MET. Lazertinib: EGFR TK

Don’t forget: SABR plus Tagrisso for oligomets or oligoprogression.”

Joe Chang: Optimal first-line treatment for EGFR-mutated mNSCLC

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