Armando Orlandi: ASCO 2025 Spotlight – Breast Cancer Trial Lineup Highlights
Armando Orlandi, Medical Director at the Agostino Gemelli University Hospital Foundation IRCCS, shared a post on LinkedIn:
“ASCO 2025: Should we call it “ASCO BREAST 2025”?
We’re less than a month away from ASCO 2025! I’m absolutely thrilled to attend what looks to be a landmark year for breast cancer research! The conference will bring us critical updates that will directly impact our clinical practice!
The agenda for this year’s conference is dominated by groundbreaking breast cancer research!
Three potentially practice-changing trials are taking center stage:
ASCENT-04: Revolutionary approach for TNBC (First Line)
DESTINY-09: Next frontier in HER2-targeted therapy (First Line)
SERENA-06: Setting new standards in endocrine therapy (First Line)
But that’s just the beginning! Look at this interesting lineup:
HER2+ Focus:
– CompassHER2 pCR: Predicting response to THP therapy
– neoCARHP: De-escalation strategies with/without carboplatin
– WSG three trials pooled analysis: Survival after de-escalated therapy
– H. Rugo’s multi-institution study: Treatment rechallenge after T-DXd-related ILD
HR+/HER2- Innovation:
– DAWNA-A: Dalpiciclib plus ET for eBC
– TRADE: Abemaciclib dose escalation in eBC
– EMBER-3: Patient-reported outcomes with imlunestrant
Advances in Metastatic Setting:
– VERITAC-2: Vepdegestrant (PROTAC) vs fulvestrant
– DHP107: Oral vs IV paclitaxel administration
– FINER study (MA.40): Fulvestrant + ipatasertib (AKTi) post-CDK4/6i progression
Treatment De-escalation and escalation:
– SHARE: Partial vs whole breast irradiation
– SOFT/TEXT: 15-year outcomes for OFS strategies
Moreover, don’t miss the Phase I/II studies that could reveal tomorrow’s breakthroughs!”
Further Reading:
ASCO 2025 for Trainees and Residents: Your Ultimate Guide to Success
ASCO 2025 Special Merit Award Recipients – Celebrating Excellence
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