Anirban Maitra: Is there a functionally consequential intratumoral microbiome in pancreatic cancer or not?
Anirban Maitra, Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center, shared a post on X:
“Is there a functionally consequential intratumoral microbiome in pancreatic cancer or not?
New study from Gulam Abbas Manji and colleagues
Low Bacterial Biomass in Human Pancreatic Cancer and Adjacent Normal Tissue
In this study, Gulam examined both FFPE and frozen tissues from patients receiving gemcitabine based neoadjuvant therapy and treatment naive cases. The former included patients with variable (long term v short term) survival. Low bacterial biomass was seen across all samples including tumor and adjacent normal.
Maybe it’s not the absolute quantity of intratumoral bacteria in pancreas cancer but the spatial localization and functional impact of even low numbers? Still not ready to write these critters off but the human data is starting to get worrisome.”
Low Bacterial Biomass in Human Pancreatic Cancer and Adjacent Normal Tissue
Authors: Michael S. May et al.
Dr. Anirban Maitra serves as a Professor of Pathology and Translational Molecular Pathology at UT MD Anderson Cancer Center since August 2013, and directs the Sheikh Ahmed Pancreatic Cancer Research Center.
He leads an NCI-funded laboratory dedicated to pancreatic cancer research, focusing on genetics and molecular pathology in human and mouse models. His research aims to advance early detection and interception strategies to enhance patient survival rates in pancreatic cancer.
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