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Ahmed Kotb: Ph-like ALL Signaling Pathways and Targets
sciencephoto.com
Jan 9, 2025, 16:35

Ahmed Kotb: Ph-like ALL Signaling Pathways and Targets

Ahmed Kotb, Hematologist and Bone marrow transplanter at King Faisal Specialist Hospital International Holding Company, shared a post on X:

“Ph-like ALL Signaling Pathways and Targets.

JAK-STAT Signaling:

  • Altered by CRLF2, JAK2, EPOR
  • Targets: JAK inhibitors, PI3K/mTOR inhibitors

ABL Signaling:

  • Fusion proteins (ABL1/2, PDGFRA/B)
  • Targets: Kinase inhibitors (dasatinib)

Other Signaling:

  • Rare fusion(NTRK3, FLT3.”

Ahmed Kotb: Ph-like ALL Signaling Pathways and Targets

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