Wafik S. El-Deiry: Dopamine pre-treatment impairs the anti-cancer effect of integrated stress response- and TRAIL pathway

Wafik S. El-Deiry shared a post on X:

“Pleased to share published paper:

Dopamine pre-treatment impairs the anti-cancer effect of integrated stress response- and TRAIL pathway-inducing ONC201, ONC206 and ONC212 imipridones in pancreatic, colorectal cancer but not DMG cells.”

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Source: Wafik S. El-Deiry/X

Wafik El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals.Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry made important contributions in cell death signaling and our understanding of the sensitivity of tumors to chemotherapy. El-Deiry has more than 400 peer-reviewed publications and 5 edited books.