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Todd Scarbrough: RTOG 0022 Final Report
Nov 26, 2023, 17:37

Todd Scarbrough: RTOG 0022 Final Report

Todd Scarbrough, Radiation Oncologist at Northeast Alabama Regional Medical Center, posted the following on X/Twitter:

RTOG 0022 Final Report. At 12 years, 9 of 10 radonc head/neck patients had no local recurrence. But only 6 of 10 patients alive! Which proves that the only EBM-based, literature-verified, 100% proven RT cure is to die before there is a local recurrence.

As far as I can tell, and as far as I know, since Kaplan-Meier curves started being used to measure local control in radonc since the 1960s, not a single person who was ever censored (from death) in a KM analysis ever had a local recurrence. Radiotherapy’s record is unblemished.

One other thing… RTOG 0022 trialists defined success as a <35% LRF rate at 2y There was a 10% 2y LRF Which reminds us that in this field of oncology, be prepared to have your preconceived notions challenged on a routine and annoying basis.

JUST ONE MORE THING… In a local control analysis using Kaplan Meier actuarial analysis, all these things are mathematically and statistically equivalent, by historical and widespread convention:

*No recurrence
*Loss to follow up
*Death”

Read more here.
Source: Todd Scarbrough/X