Sébastien Couraud: Alexis Cortot about air pollutants interactions with lung cancers molecular alerations

Jill Feldman shared a post by Sébastien Couraud, Professor of Pulmonology, Université Lyon, on X, adding:

“Why hasn’t there been more discussion about this study? I’m surprised because it clearly shows another carcinogenic pathway (potentially targetable?) and the need to discuss screening strategies!

At ESMO24 Dr Alexis Cortot presented data from a French study that showed a significant association between PM 2.5 levels and EGFR+ lung cancer, CONFIRMING the findings that Charles Swanton presented at ESMO22 showing a significant association between levels of PM2.5 & EGFR-mutated lung cancer.

Reducing pollution is obvious, although not easily done. The difficult part is understanding the biological process, how PM2 impacts tumors & identifying those at risk. Let’s get to work!”

Quoting Sébastien Couraud:

“Fascinating presentation of Prof. Alexis Cortot about air pollutants interactions with lung cancers molecular alerations. Data coming from KBP-CPHG-2020 study from Collège des Pneumologues des Hôpitaux Généraux.

Confirming association found by Charles Swanton between PM2.5 exp and EGFR mut.”

Source: Jill Feldman/X and Sébastien Couraud/X

Jill Feldman is a lung cancer patient and advocate. She is the Co-Founder EGFR Resisters, an advocacy group of EGFR positive lung cancer patients who are resistant to targeted treatment. She is the Past President of the LUNGevity Foundation, Deputy Chair of IASLC’s patient advisory board and a member of The Chicago Institute of Translational Medicine’s patient advisory board. Jill is a member of the programmatic panel for the Department of Defense Lung Cancer Research Program, a planning committee member on IASLC’s North America Conference on Lung cancer and as a member of the the ECOG-ACRIN Research Group’s patient advocate committee and thoracic committee.