Pawel Kalinski: The use of TAAs as ubiquitous targets for adoptive T cell therapies in solid tumors

Pawel Kalinski, Senior Vice President for Team Science at Roswell Park Comprehensive Cancer Center, shared on LinkedIn:

“Contratulatuons to Dr. Dong for his impressive PhD thesis and for this critical contribution to our understanding of how cytotoxic lymphocytes (CTLs) can selectively recognize low levels of unmutated tumor-associated antigens (TAAs) on cancer cells, but not the same antigens expressed by healthy tissues

Best wishes for his postdoctoral research at our lab in developing a new class of T cell therapies, using dual recognition by TCR (or CAR) and NK receptors (NKRs) to allow the use of TAAs as ubiquitous targets for adoptive T cell therapies (ACT) in solid tumors.

‘NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs‘

Authors: Bowen Dong, Natasa Obermajer, Takemasa Tsuji, Junko Matsuzaki, Cindy M Bonura, Cindy Sander, Henry Withers, Mark D Long, Colin Chavel, Scott H Olejniczak, Hans Minderman, John M Kirkwood, Robert P Edwards, Walter J Storkus, Pedro Romero, Pawel Kalinski. ”

Source: Pawel Kalinski/LinkedIn