Wafik S. El-Deiry: Understanding the Biology of Clustered CTCs

Wafik S. El-Deiry shared on X:

“Superhydrophobic Array Devices for the Enhanced Formation of 3D Cancer Models ‘Clustered CTCs have greater shear stress and treatment resistance, yet their biology remains poorly understood.’

‘cancer cell aggregates of various sizes with immortalized cancer cell lines… exhibited higher E-cadherin expression and are significantly more capable of surviving high fluid shear stress-related forces compared to single cells and model clusters grown using the control method, helping to explain why clustering may provide a metastatic advantage.'”

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Source: Wafik S. El-Deiry/X

Wafik S. El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals.

He is the Editor in Chief at Oncotarget. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.