April, 2025
April 2025
M T W T F S S
 123456
78910111213
14151617181920
21222324252627
282930  
Molecular differences in early-onset biliary tract cancer
Aug 9, 2024, 07:05

Molecular differences in early-onset biliary tract cancer

Erman Akkus, Medical Oncology Fellow at Ankara University Faculty of Medicine, posted on X about recent paper by Thejus Jayakrishnan et al., titled “Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers” published on JCO Precision Oncology.

Authors: Thejus Jayakrishnan, Yasmine Baca, Joanne Xiu, Mehrie Patel, Benjamin A. Weinberg, Emil Lou, Jashodeep Datta, Moh’d Khushman, Pat Gulhati, Sanjay Goel, Tiago Biachi de Castria, Vaia Florou, Kanika G. Nair, Suneel D. Kamath, Alok A. Khorana

Molecular differences in early-onset biliary tract cancer

Molecular differences in early-onset biliary tract cancer (EO-BTC)

5,587 patients (8.1% EO-BTC)

EO-BTC

  • FGFR2 fusion (15.7% v 5.9% Q < 0.001)
  • NIPBL fusion (1.1% v 0%; Q < 0.001)
  • Higher angiogenesis

Average-onset-BTC

  • Higher interferon gamma-IFG score
  • Higher T-cell–inflamed signature

Access to NGS and FGFR targeted treatments are especially crucial for young patients.”

Source: Erman Akkus/X