María Natalia Gandur Quiroga: Exciting advancements in Synthetic Biology for CAR T cell improvement!

Quoting María Natalia Gandur Quiroga, Chief of the Division of Genitourinary Medical Oncology at the Angel H.Roffo Institute, on X/Twitter:

”Exciting advancements in Synthetic Biology for CAR T cell improvement!
Enhanced antigen recognition using Logic gating (OR, NO, AND) for better cancer targeting.
Contextual programming: tools like switch receptors, protein degradation, synthetic promoters, and epigenetic modulation for precise CAR T cell functions.
Machine learning aids multiplex gene control for better T cell functionalities.
Overcoming delivery challenges: non-viral methods offer better safety & large genetic payload integration.

Conclusion Highlights:
Entering a new era of therapeutic development with live cell engineering.
Effective CAR T therapy needs strategies for safety & efficacy.
Prioritizing 3 key biological requirements with technical solutions.
Emphasis on multiplexing tools for multiple biological needs.
Progress in delivering extensive genetic info vital for advanced cell engineering.
Collaboration across academia & industry essential.  

A united goal: enhancing survival rates for cancer patients.”

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Source: Dra.María Natalia Gandur Quiroga/Twitter