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Erman Akkus: May immune-inflammation stimulation by vaccines interact with MSI-H status?

Photo from Erman Akkus/X

Jul 10, 2024, 12:49

Erman Akkus: May immune-inflammation stimulation by vaccines interact with MSI-H status?

Erman Akkus, Medical Oncology Fellow at Ankara University Faculty of Medicine, shared on X:

“We have performed a hypothesis-generating case control study

dMMR (MSI-H) is associated with immune infiltration-activation, so, may immune-inflammation stimulation by vaccines interact with MSI-H status?

Among non-metastatic CRC patients diagnosed during Covid pandemic:

Patients with dMMR CRC had significantly higher mRNA-based (BNT162b2) vaccine before diagnosis.
No difference in CoronoVac.
dMMR-BNT162b2 group had higher CRP, sedimentation and lower lymphoctye/CRP ratio at the diagnosis.”

Erman Akkus: May immune-inflammation stimulation by vaccines interact with MSI-H status?

Source: Erman Akkus/X

Ankara University Faculty of Medicine BNT162b2 cancer colorectal cancer CoronaVac COVID-19 pandemic CRC CRP dMMR Erman Akkus immune activation Immune Infiltration Lymphocyte/CRP Ratio medical oncology mRNA Vaccine MSI-H OncoDaily Oncology Sedimentation vaccines

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