Vivek Subbiah: Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling
Vivek Subbiah, Chief of Early-Phase Drug Development at Sarah Cannon Research Institute, shared a post on LinkedIn about recent paper published in NEJM.
“Sharing an interesting case that was published in NEJM.
Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling. In a patient with pathogenic ZAP70 mutations and HPV19-integrated SCC, restoring T-cell receptor signaling by stem-cell transplantation resolved HPV-related disease, revealing a direct oncogenic role for β-HPV in immunodeficiency.”
Title: Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling
Authors: Peiying Ye, Jenna R.E. Bergerson, Isaac Brownell, Gabriel J. Starrett, Roshini S. Abraham, Megan V. Anderson, Triscia Martin, Derek MacMath, Hye Sun Kuehn, Jyothi Padiadpu, Siqi Zhao, Sergio D. Rosenzweig, Roxane Tussiwand, Warren J. Leonard, Stefania Pittaluga, Mark Raffeld, Danielle E. Arnold, and Andrea Lisco
Read The Full Article at NEJM.
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