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Armando Orlandi: Tackling One of the Rarest and Most Challenging Topics in Breast Oncology
Jul 13, 2025, 15:43

Armando Orlandi: Tackling One of the Rarest and Most Challenging Topics in Breast Oncology

Armando Orlandi, Medical Director at the Agostino Gemelli University Hospital Foundation IRCCS, shared a post on LinkedIn:

“Outstanding achievement by the BEAM Study Group!

Tackling one of the rarest and most challenging topics in breast oncology requires exceptional dedication and international collaboration. This remarkable team has successfully addressed the critical knowledge gap in malignant mesenchymal breast tumors!

BEAM Study: The largest European experience on malignant mesenchymal breast tumors

  • 113 patients across 11 European breast units
  • 20-year observational analysis
  • 10-year overall survival: 75.2%

Key findings:

  • Mixed cases emerge as a distinct high-risk entity
  • Surgery with negative margins remains the cornerstone of treatment
  • Need for new strategies, particularly for high-risk subtypes

Special congratulations to Alejandro Martin Sanchez, Prof. Gianluca Franceschini for their masterful coordination of this complex multicentric study!

When rare diseases affect <1% of breast malignancies, it takes visionary leadership and meticulous teamwork to generate evidence that changes clinical practice.

This is one way how we advance science in rare diseases!​​​​​​​​​​​​”

Title: Long term outcomes of breast primary sarcomas and malignant phyllodes tumors: 20 years observational analysis of the BEAM∗ study group. (∗the breast European association for mesenchymal tumors)

Journal: European Journal of Surgical Oncology

Authors: Alejandro M. Sanchez, Flavia De Lauretis, Angela Bucaro, Chiara V. Pirrottina, Niccolò Borghesan, Antonio Franco, Lorenzo Scardina, Diana Giannarelli, Alba Di Leone, Riccardo Masetti, Armando Orlandi, Alessandra Fabi, Antonella Palazzo, Ilaria Poli, Angela Santoro, Antonino Mulè, Nicoletta D’Alessandris, Fabio Marazzi, Valeria Masiello, Valeria Verusio, Paolo Veronesi, Elisabetta Pennacchioli, Denise Mattar, Renato Lobrano, Roberta Brancaccio, Virginia Ferraresi, Elisa Concetta Onesti, Sabrina Vari, Damiano Gentile, Corrado Tinterri, Yazan Masannat, Jessica Lendore, Ammara Rasheed, Cynthia Aristei, Valeria Epifani, Maria Pia Foschini, Antonio Maestri, Elisa D’Angelo, Maria Cristina Cucchi, Antonella Baldissera, Bruno Vincenzi, Valeria Vitale, Augusto Lombardi, Francisco Javier Cejas Arjona, Pilar Rioja Torres, Krishna Clough, Jenny C. Millochau, Gianluca Franceschini

Read the full article.

Armando Orlandi

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