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Giuseppe Banna: Key Mechanisms Behind Brain Metastasis in Lung Cancer Patients with Low BMI
Giuseppe Banna/LinkedIn
Jul 2, 2025, 08:51

Giuseppe Banna: Key Mechanisms Behind Brain Metastasis in Lung Cancer Patients with Low BMI

Giuseppe Banna, Consultant Medical Oncologist at Portsmouth Hospitals University NHS Trust, shared a post on LinkedIn about a paper he co-authored with colleagues published in Nature Communications:

“Excited to share our new publication in Nature Communications, uncovering key mechanisms behind brain metastasis in lung cancer patients with low BMI!
In the paper ‘Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI’, we reveal how low BMI triggers ghrelin-GHSR signalling, increasing neuronal neuropeptide Y (NPY) secretion that drives tumour metabolic reprogramming and facilitates brain colonisation.
By analysing data from over 7,600 patients, we confirm the “obesity paradox” and identify promising biomarkers and therapeutic targets such as the NPY-Y5R pathway, paving the way for tailored interventions in lung cancer patients with low BMI.
Huge thanks to Abhishek Tyagi, Shih-Ying Wu, Jee-Won Kim, Ravindra Pramod Deshpande, Kerui Wu, Eleanor C. Smith, and Kounosuke Watabe for the amazing collaboration.”

Title: Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI

Authors: Abhishek Tyagi, Shih-Ying Wu, Jee-Won Kim, Ravindra Pramod Deshpande, Kerui Wu, Eleanor C. Smith, Giuseppe L. Banna and Kounosuke Watabe.

You can read the Full Article in Nature Communications.

Giuseppe Banna: Key Mechanisms Behind Brain Metastasis in Lung Cancer Patients with Low BMI

More posts featuring Giuseppe Banna.

Abhishek Tyagi BMI brain metastasis Brain Metastasis in Lung Cancer cancer Eleanor C. Smith Giuseppe Banna Jee-Won Kim Kerui Wu Kounosuke Watabe Lung cancer Nature Communications OncoDaily Oncology Ravindra Pramod Deshpande Shih-Ying Wu
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