Patrick Hwu: Why Don’t Some Immune Cells Perform Well in the Fight Against Cancer?
Patrick Hwu, President and CEO of Moffitt Cancer Center, shared a post on LinkedIn about a paper by No-Joon Song et al. published in Cancer Discovery:
“Why don’t some immune cells perform well in the fight against cancer?
In this study, No-Joon Song et al. found that certain natural killer (NK) cells inside tumors can actually block the growth of the CD8+ T cells we need to fight cancer, while allowing more exhausted, less effective T cells to take over.
This helps explain why some tumors resist immunotherapy and continue growing, even when the immune system is activated.
By targeting these NK cells, we may be able to restore the right kind of T cells and improve treatments like immune checkpoint inhibitors.
Read the full study in AACR Journals.”
Title: Tumor-Associated NK Cells Regulate Distinct CD8+ T-cell Differentiation Program in Cancer and Contribute to Resistance against Immune Checkpoint Blockers
Authors: No-Joon Song, Juan Xie, Kyeong Joo Jung, Yi Wang, Joanna Pozniak, Niccolo Roda, Jean-Christophe Marine, Brian P. Riesenberg, Hyeongseon Jeon, Anjun Ma, Nathanael Cox, Darren Wethington, Kelsi Reynolds, Tong Xiao, Anqi Li, Parker Kronen, Nicholas Denko, David P. Carbone, Qin Ma, William E. Carson III, Bethany L. Mundy-Bosse, Christin E. Burd, Jayajit Das, Dongjun Chung, Zihai Li
You can read the Full Article in Cancer Discovery.
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