Francesco Maura: Biallelic Antigen Escape is a Mechanism of Resistance to Anti-CD38 Antibodies in MM
Francesco Maura, Associate Director of Myeloma Research Institute at the University of Miami, shared a post on X:
“Happy to share our new work out today on Blood Journals Portfolio, where we report CD38 loss as a recurrent mechanism of resistance to anti-CD38 antibody in multiple myeloma. Great collaboration between Memorial Sloan Kettering Cancer Center, Memorial Sloan Kettering Department of Medicine, University of Calgary, Heidelberg Myeloma, and Mayo Clinic.
Key findings: CD38 loss after anti-CD38 monoclonal antibody occurs more often than expected (10–20%). We also found mutations that keep CD38 expression intact but block anti-CD38 binding.
Interestingly, these events are observed later in time, often after the second exposure to anti-CD38 monoclonal antibody.
Here is the X/Twittorial we released a few months ago, summarizing in more detail the key findings.
This study was led by my incredible collaborator and friend Ben Diamond, who works very closely with Linda B. Baughn, Alexandra Poos, and Mansour Poorebrahim to characterize and functionally validate these events. Thanks also to Sanofi Myeloma for their help with CD38 3D protein modeling.
Huge thanks to our amazing collaborators Vincent Rajkumar, Rafael Fonseca, Nizar Jacques Bahlis, Shaji Kumar, Marc S. Raab, Niels Weinhold for supporting this study and enabling so many great and ongoing collaborations!”
Title: Biallelic antigen escape is a mechanism of resistance to anti-CD38 antibodies in multiple myeloma
Authors: Benjamin T. Diamond, Linda B Baughn, Mansour Poorebrahim, Alexandra M Poos, Holly Lee, Marcella Kaddoura, J Erin Wiedmeier-Nutor, Michael A. Durante, Gregory E Otteson, Dragan Jevremovic, Hongwei Tang, Stefan Fröhling, Marc-Andrea Baertsch, Marios Papadimitriou, Bachisio Ziccheddu, Tomas Jelínek, Cendrine Lemoine, Alexey Rak, Damian J Green, Carl Ola Landgren, Paola Neri, Peter Leif Bergsagel, Esteban Braggio, Shaji K Kumar, Marc S. Raab, Rafael Fonseca, Nizar Bahlis, Niels Weinhold, Francesco Maura.
You can read the Full Article in Blood.
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