Patrick Hwu/mdanderson.org
Jun 8, 2025, 08:01
Patrick Hwu: How Can We Make Cancer-Fighting T cells Stronger and Longer-Lasting?
Patrick Hwu, President and CEO of the Moffitt Cancer Center, shared a post on X about a paper by Yating Zheng et al. published in Science Immunology:
“Science Saturday.
How can we make cancer-fighting T cells stronger and longer-lasting? In this study, Zheng et. al engineered a viral protein to ‘rewire’ how T cells receive survival signals-activating STAT5, a key pathway that helps T cells persist and stay functional, without needing cytokines like IL-2.
These modified T cells resisted exhaustion and controlled tumors better in models of melanoma and lymphoma, showing a new way to enhance immunotherapy for solid tumors. This strategy offers a powerful tool to boost T cell therapies against cancer. Read the full study in Science Immunology.”
Title: An engineered viral protein activates STAT5 to prevent T cell suppression
Authors: Yating Zheng, Zehui Gu, Claire E. Shudde, Taylor L. Piper, Xinyu Wang, Grace A. Aleck, Jiajia Zhou, Dana King, Monica K. Chanda, Lilliana Trinch, Weiping Zou, Adam H. Courtney.
You can read the Full Article in Science Immunology.
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