Rachit Khandelwal/X
Apr 27, 2025, 10:55
Rachit Khandelwal: Glucarpidase for treatment of high-dose methotrexate toxicity
Rachit Khandelwal, Pediatrics BMT fellow at Medanta The Medicity, shared an article by Shruti Gupta, et al. on X:
“Glucarpidase for treatment of high-dose methotrexate toxicity.
MTX-AKI? Think glucarpidase.
In a multicenter study (n=708), glucarpidase use was linked to:
- 2.7x ↑ kidney recovery.
- Faster renal recovery (aHR 1.88).
- ↓ grade ≥2 neutropenia & transaminitis.
- No change in mortality.
A potential game-changer in managing MTX toxicity.”
Glucarpidase for treatment of high-dose methotrexate toxicity.
Authors: Shruti Gupta, et al.
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