Bishoy Faltas: Spatial-temporal eDNA diversity in urothelial carcinoma and tumor immunity
Bishoy Faltas, Chief Research Officer at the Englander Institute for Precision Medicine and an Associate Professor of Medicine and Cell and Developmental Biology at Weill Cornell Medicine, shared a post on X about a paper he co-authored with colleagues published in Cancer Discovery:
Authors: Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Huiying Tao, Bishoy Faltas, Jens Luebeck, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han et al.
“Excited to be part of this international collaborative effort, now published in Cancer Discovery! Great to see validation of our findings on extrachromosomal DNA (initially published in Nature) in an independent cohort of 595 urothelial cancer whole genomes:
- High prevalence of ecDNA events in UC
- Recurrent CCND1 amplification events within ecDNA forming SVs
This work further builds on these findings, investigating the Spatial-Temporal Diversity of ecDNA
- ecDNA can arise in flat urothelial lesions
- ecDNA is associated with shortened patient survival
- ecDNA is linked to a distinct TIME
- The same tumors can have both clonal and subclonal ecDNA events, suggesting ongoing ecDNA biogenesis
- ecDNA can be detected with high specificity from sequencing urinary sediments
Check out the paper.”
Sumanta Pal, Medical Oncologist at City of Hope, shared this post, adding:
“You never cease to amaze, Bishoy Faltas! Terrific work as always.”
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