Nina Niu Sanford: An overview of GI radiation oncology
Nina Niu Sanford, Assistant Professor and Chief of Gastrointestinal Radiation Oncology at Harvard/Brigham and Women’s Hospital/Massachusetts General Hospital, posted on X:
“A 33 min overview of GI radiation oncology!
I made this video for an oral boards review course, sharing here.
It’s just 5 slides (below) and me talking the whole time, so you can just listen. Hope it’s helpful!
Esophagus/GEJ/Gastric
ESOPEC was practice-changing: peri-op FLOT is SOC in many settings, but here are some scenarios to consider RT.
FYI – did not include older trials (INT0116) and several negative gastric studies (CRITICS, ARTIST I/II)
Pancreas
Practice patterns vary widely with regards to when to give RT, dose/fractionation of RT, treatment volumes. Level 1 evidence is admittedly limited. I think this is a reasonable approach.
Rectal
TNT is a safe bet for most locally advanced cases, but also do need to know scenarios for RT omission. Don’t forget MSI testing – MSI-H tumors get upfront IO.
Hepatobiliary
Liver and cholangiocarcinoma. Obviously, a complex topic for 1 slide particularly given multiple local therapy options (Y90, ablation, TACE, etc). Here are main indications for RT. Also typo in video – should be IMBRAVE150 not 050.
Anal
Probably the most straight forward – definitive chemoRT for early stage and locally advanced. Same paradigm since 1970s. Ongoings trials on treatment de-escalation and intensification. That’s it! Let me know any feedback.”
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