Heidi Ko: The distinct metabolic pathways in 149 real-world breast cancer samples
Heidi Ko, Medical Director, Medical Affairs, shared on LinkedIn
“Come see me at poster session 3, 1-24
Our study investigated the distinct metabolic pathways in 149 real-world breast cancer samples.
Gene expression data for 395 immune-related genes were collected using RNA sequencing (RNA-seq). Metabolic signatures for various pathways (carbohydrate, lipid, protein, and vitamin/cofactor metabolism) were calculated based on gene expression.
What did we find?
TNBC was found to be more metabolically active overall compared to non-TNBC, with significant differences in lipid, protein, and vitamin/cofactor metabolism.
The survival effects vary depending on the specific metabolic pathway involved. Certain metabolic signatures were associated with better survival outcomes in both TNBC and non-TNBC cohorts.
As we look into the future, an improved understanding of the metabolic and tumor immune microenvironment of breast cancer may facilitate a more nuanced characterization of molecular subtypes and development of therapeutic strategies targeting these pathways.
Thanks for stopping by, Kai Pollard! ”
-
ESMO 2024 Congress
September 13-17, 2024
-
ASCO Annual Meeting
May 30 - June 4, 2024
-
Yvonne Award 2024
May 31, 2024
-
OncoThon 2024, Online
Feb. 15, 2024
-
Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023