James P. Crowley: New Paradigm for DNA Repair Research
James P. Crowley, Professor of Medicine emeritus at Brown University, shared a post on LinkedIn:
“The DNA damage response (DDR) is a network of proteins that coordinate DNA repair and cell-cycle checkpoints to prevent damage being transmitted to daughter cells. DDR defects lead to genomic instability, which enables tumour development, but they also create vulnerabilities that can be used for cancer therapy.”
“Dr Lilian Kabeche presented a seminar on a new paradigm for DNA repair research today at Brown University graduate program in molecular biology.
Her lab at Yale has elucidated that while members of the DNA damage response pathway (DDR) function in mitosis to ensure that chromosomes are correctly segregated, interact with the immune system, and promote cell-autonomous and non-autonomous mechanisms to eliminate damaged cytosolic DNA and regulate genome integrity through epigenetic regulation of the centromere, there is more going on here than has been previously thought.
This work in her lab and other labs also, seriously shifts the current paradigm that components of the DNA damage response pathway have a singular function- to recognize and repair DNA and are quiescent or as Professor Kabeche cleverly illustrates it, most of the rest of the time to a much more interesting and exciting role which will perhaps will open up new some avenues for studying and also treating cancer.”
James P. Crowley is a Professor of Medicine Emeritus at Brown University and serves as a volunteer physician at the Rhode Island Free Clinic. He has held leadership positions in the medical community, including past President of the Rhode Island Medical Society and the last President of The Providence Medical Association.
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