Maryam Lustberg: How minocycline Affects Cognition and Inflammation in Breast Cancer Survivors on Chemotherapy

Maryam Lustberg shared a post on Linkedin:

”Neuroinflammation from chemotherapy andover activated Microglia contribute to cancer related affective and cognitive changes. These changes mitigated by minocycline in animal models.

Same efficacy unfortunately not seen in our study in humans although patients with preexisting depressive symptoms may have had a small benefit in this pilot randomized study.”

Effect of minocycline on changes in affective behaviors, cognitive function, and inflammation in breast cancer survivors undergoing chemotherapy: a pilot randomized controlled trial

Authors: Zihan Melink, Maryam B. Lustberg, Patrick M. Schnell, Jessica, Mezzanotte-Sharpe and Tonya S. Orchard.

Dr. Maryam Lustberg is the Director of the Center for Breast Cancer at Smilow Cancer Hospital and Yale Cancer Center, and Chief of Breast Medical Oncology at Yale Cancer Center. She is also an Associate Professor of Medicine (Medical Oncology). She has been recognized for her patient-focused care with awards that include being rated by Forbes as one of the top breast medical oncologists in the nation and named to the Castle Connolly list of “Regional Top Doctors,” and “Exceptional Women in Medicine” for 2020.

Dr. Lustberg is a member of the ASCO Annual Meeting Education Committee, Patient and Survivor Care Education Committee, and Neuropathy Expert Guideline Panel. She is the immediate past President for the International Organization Multinational Association of Supportive Care in Cancer (MASCC). She serves as an Associate Editor for the Journal of Cancer Survivorship.