Patrick Hwu: The mechanism behind increased IL-1 production and cancer progression

Patrick Hwu shared a post on LinkedIn:

“Cancer incidence increases with age, but what is the mechanism behind this?

A recent study by Miriam Merad and colleagues utilizing a murine model of Lung Cancer found that increased IL-1 production and accumulation of myeloid cells in the lungs of older mice promoted cancer progression and that blocking IL-1 or its receptor could decrease tumor growth.

This is an especially important finding since there are already available clinical agents that block the IL-1 pathway.”

Source: Patrick Hwu/LinkedIn

Hematopoietic aging promotes cancer by fueling IL-1⍺–driven emergency myelopoiesis

Authors: Matthew D. Park, Jessica Le Berichel, Pauline Hamon, C. Matthias Wilk, Meriem Belabed, Nader Yatim, Alexis Saffon, Jesse Boumelha, Chiara Falcomatà, Alexander Tepper, Samarth Hegde, Raphaël Mattiuz, Brian Y. Soong, Nelson M. Lamarche, Frederika Rentzeperis, Leanna Troncoso, Laszlo Halasz, Clotilde Hennequin, Theodore Chin, Earnest P. Chen, Amanda M. Reid, Matthew Su, Ashley Reid Cahn, Laura L. Koekkoek, Nicholas Venturini, Shira Wood-Isenberg, Darwin D’Souza, Rachel Chen, Travis Dawson, Kai Nie, Zhihong Chen, Seunghee Kim-Schulze, Maria Casanova-Acebès, Filip K. Swirski, Julian Downward, Nicolas Vabret, Brian D. Brown, Thomas U. Marron, and Miriam Merad.

Patrick Hwu, MD, currently serves as the President and CEO of Moffitt Cancer Center. With a focus on understanding the dynamics between tumors and the immune system, Dr. Hwu’s research has been pivotal in advancing gene-modified T cell therapy.
He notably contributed seminal work on the development of the first chimeric antigen receptor aimed at combating cancer. His research portfolio extends to vaccines, adoptive T-cell therapies, and mechanisms of immune resistance.