The EP3-ZNF488 Axis Promotes Self-Renewal of Glioma Stem-Like Cells to Induce Resistance to Tumor Treating Fields
, Director of USC Norris and the H. Leslie and Elaine S. Hoffman Professor in Cancer Research, shared an article by Dongjiang Chen, et al. on LinkedIn:
“Tumor Treating Fields (TTFields) use low-intensity electric fields to disrupt cancer growth and are approved for multiple cancers, including aggressive brain cancer such as glioblastoma. However, cancer stem cells can develop resistance to this treatment over time.
Published in Cancer Research, USC Norris members Drs. David Tran and Bodour Salhia, Ph.D have uncovered a key “master switch” behind this resistance involving two key proteins—EP3 and ZNF488. These proteins form a complex that allows cancer stem cells to survive and renew themselves, fueling resistance to TTFields.
Remarkably, by blocking the EP3-ZNF488 axis, scientists can not only restore the effectiveness of TTFields in cancer cells that had previously become resistant, but also preemptively halt the development of resistance altogether.
This discovery is not limited to glioblastoma, as the EP3-ZNF488 axis was also found in other cancers, suggesting the same resistance mechanism could be at work in various cancers, potentially offering a new target for improving treatment outcomes in many cancers.”
Authors: Dongjiang Chen, et al.
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