Rahul Banerjee: Pooled Data for Dose Mods from DREAMM-7 and DREAMM-8
Rahul Banerjee, Assistant Professor at Fred Hutchinson Cancer Center at the University of Washington, shared a post on X by Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, adding:
“Great Blood Advances paper by María-Victoria Mateos, Meletios Athanasios Dimopoulos et al: pooled data for dose mods from DREAMM-7 and -8.
With bela-maf in Multiple Myeloma, dose de-escalations are not the exception… they are the norm!
Over 70% of pts with responses had ≥3 separate dose interruptions in both trials.”
Quoting Robert Orlowski‘s post:
“Myeloma Paper of the Day: Modification of belantamab mafodotin dosing to balance efficacy and tolerability in DREAMM-7 and DREAMM-8 trials still produced median PFS in patients with ≥1 dose delay of ≥12 weeks of 36.6 months and NR, respectively.”
Title: Modification of Belantamab Mafodotin Dosing to Balance Efficacy and Tolerability in the DREAMM-7 and DREAMM-8 Trials
Authors: Maria-Victoria Mateos, Suzanne Trudel, Hang Quach, Pawel Robak, Meral Beksac, Ludek Pour, Marek Hus, Kihyun Kim, Vera Zherebtsova, Sosana Delimpasi, Tomas Jelínek, Christopher Ward, P Joy Ho, Vladimir I Vorobyev, Marcelo Pitombeira Lacerda, Gracia Aparecida Martinez, Ivan Spicka, Jakub Radocha, Michele Cavo, Claudio Cerchione, Chengcheng Fu, Kazuhito Suzuki, Rachel Rogers, Amy Phillips-Jones, Zhaohui Wang, Hena Baig, Jodie Wilkes, Xiaoou L Zhou, Eric Lewis, Lydia Eccersley, Neal Sule, Prani Paka, Joanna B Opalinska, Pralay Mukhopadhyay, Vania Tietsche de Moraes Hungria, Meletios Athanasios Dimopoulos
You can read the Full Article in the National Library of Medicine.
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