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Angela Mastronuzzi: New Findings on High-Grade Glioma with Pleomorphic and Pseudopapillary Features
Angela Mastronuzzi/LinkedIn
May 15, 2025, 07:57

Angela Mastronuzzi: New Findings on High-Grade Glioma with Pleomorphic and Pseudopapillary Features

Angela Mastronuzzi, Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital and President of AIEOP, shared a post on LinkedIn:

“‘Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases’
High-grade glioma with pleomorphic and pseudopapillary features (HPAP) is a recently identified methylation cluster of tumors showing a circumscribed glioma phenotype with diverse histological appearances.
We here in describe two tumors showing morphological, genetic and epigenetic characteristics overall consistent with the emerging HPAP entity, adding to the limited published data. In line with existing literature, both cases displayed features of a circumscribed glioma with perivascular pseudorosettes, a remarkable giant cell/pleomorphic component, pseudopapillary structures and diffuse p53 expression.
While both tumors were classified as high-grade, neither patient has shown signs of disease progression to date. Our findings underscore several noteworthy features of HPAP.
Our study brings to light novel aspects of this emerging group of tumors, such as the possible association with NF2-related schwannomatosis syndrome and the evolution from a low-grade precursor, and may contribute to consider HPAP as a clinicopathological entity.”

Glioma

Title: Expanding clinicopathologic knowledge in high-grade glioma with pleomorphic and pseudopapillary features (HPAP): a report of two cases

Journal: Acta Neuropathologica Communications

Authors: Sabrina Rossi, Isabella Giovannoni, Sara Patrizi, Andrea Mafficcini, Eleonora Piccirilli, Giuseppe Kenneth Ricciardi, Giacomina Megaro, Francesca Arienzo, Chantal Tancredi, Emanuele Agolini, Andrea Carai, Angela Mastronuzzi, Caterina Giannini, Franco Locatelli, Rita Alaggio, Giovanna Stefania Colafati, Viola Alesi, Evelina Miele, Valeria Barresi

Read Full Article.

Angela Mastronuzzi: New Findings on High-Grade Glioma with Pleomorphic and Pseudopapillary Features

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