December, 2024
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Nicholas Hornstein: CtDNA in Curatively Resected Colorectal Cancer
Dec 29, 2024, 11:01

Nicholas Hornstein: CtDNA in Curatively Resected Colorectal Cancer

Nicholas Hornstein, hematologist and oncologist with Northwell Health, posted on X about recent paper by Jingran Ji et al., titled “Circulating Tumor DNA Testing in Curatively Resected Colorectal Cancer and Salvage Resection” published on JAMA.

Authors: Jingran Ji, Chongkai Wang, Ajay Goel, Kurt Melstrom, Yasmin Zerhouni, Lily Lai, Laleh Melstrom, Mustafa Raoof, Yuman Fong, Andreas Kaiser, Marwan Fakih

Nicholas Hornstein: CtDNA in Curatively Resected Colorectal Cancer

“Hot off the presses!

ctDNA in Curatively Resected Colorectal Cancer.
184 patients (mostly Stage II/III).
No OS/DFS. 3 month lead time for ctDNA. Most recurrences occurred in the liver.
Only 1.6% remained disease free following their metastectomy. Take away? Unclear if waiting for radiographic progression and surgery is best. Systemic therapy likely preferable in these patients… More studies to come soon.

Nicholas James Hornstein, MD, PhD, is a hematologist and oncologist with Northwell Health in New York. He specializes in the diagnosis and treatment of blood disorders and cancers, providing comprehensive care to his patients. Dr. Hornstein also serves as an Assistant Professor at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.