Insight

Alessandro Di Federico: Sensitivity of BRAF class 3 Mutations to EGFR-TKIs

Alessandro Di Federico/X

Dec 10, 2024, 14:10

Alessandro Di Federico: Sensitivity of BRAF class 3 Mutations to EGFR-TKIs

Alessandro Di Federico, Medical Oncologist and Ph.D. student at the University of Bologna, shared a post on X:

“BRAF class 3 mutations are a group of missense mutations found in ~1% of NSCLCs. Patients with these tumors are currently orphan of targeted therapies.
In our study just published in JCO Precision Oncology we investigated their sensitivity to EGFR-TKIs.

BRAF class 3 mutations are characterized by “dead” BRAF kinase domain, c-RAF heterodimerization, & are thought to amplify a pre-existing RAS signal (thus, their RAS dependance) already triggered by various mechanisms, including upstream tyrosine kinase receptors (e.g., EGFR).

We identified 2 patients harboring BRAF class 3 mutations as the only driver oncogene (EGFR wt) who responded to the EGFR-TKI erlotinib, given as per the BR.21 study. We then performed analyses “from bedside to bench” on cell lines to better understand these responses.

Although preliminary, we hope our results will pave the way for new therapies for these patients and offer a better understanding of their tumors.
This study was done University di Bologna and University di Pavia thanks to the huge work of Arianna Palladini and many authors!”

Clinical and Preclinical Activity of EGFR Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer Harboring BRAF Class 3 Mutations

Authors: Alessandro Di Federico, Stefania Angelicola, Mariateresa Frascino, Irene Siracusa, Beatrice Bisanti, Francesca Ruzzi, Maria Sofia Semprini, Hugo De Jonge, Andrea De Giglio, Francesca Sperandi, Stefano Brocchi, Barbara Melotti, Francesca Giunchi, Elisa Gruppioni, Annalisa Altimari, Pier-Luigi Lollini, Andrea Ardizzoni, Arianna Palladini, Francesco Gelsomino

Alessandro Di Federico: Sensitivity of BRAF class 3 Mutations to EGFR-TKIs

Alessandro Di Federico Andrea Ardizzoni Andrea De Giglio Annalisa Altimari Arianna Palladini Barbara Melotti Beatrice Bisanti Elisa Gruppioni Francesca Giunchi Francesca Ruzzi Francesca Sperandi Francesco Gelsomino Hugo De Jonge Irene Siracusa Maria Sofia Semprini Mariateresa Frascino Pier-Luigi Lollini Stefania Angelicola Stefano Brocchi

Giuliana Rancic and Breast Cancer: How She Went Against, How She Survived, and More

Vincent Rajkumar: Paradigm changing AQUILA randomized trial in high risk smoldering myeloma

"The Doctor Who Always Has Candies in His Pocket": A Conversation with Professor Guangchao Zhang, Pioneer of Pediatric Surgical Oncology in China

Highlights from Global Cancer Movement: Challenging the Status Quo in Colorectal Cancer - Day 3

Wanda Sykes and Breast Cancer: How She Went Against, How She Survived, and More

Special Coverage