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Erman Akkus: H. Pylori and Colorectal Cancer
Mar 6, 2024, 10:44

Erman Akkus: H. Pylori and Colorectal Cancer

Erman Akkus, Medical Oncology Fellow at Ankara University, shared on X/Twitter:

H. Pylori and Colorectal Cancer! H. pylori positivity > higher colorectal cancer (CRC) incidence and mortality, especially in untreated individuals.

  • Retrospective cohort
  • 812,736 individuals tested, 205,178 (25.2%) positive
  • H. pylori positive group > higher 5-, 10-, and 15-year cumulative CRC incidences (log-rank test P < .0001), higher incident and fatal CRC risk (HR 1.18 and 1.12)
  • Treatment versus no treatment> lower CRC incidence and mortality (absolute risk reduction 0.23%-0.35%), untreated had higher incident and fatal CRC risk (HR 1.23 and 1.40)
  • Underlying mechanism/pathogenesis?
  • Confounding? Same lifestyle and sociaeconomical factors for both H.pylori infection and CRC?”

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Source: Erman Akkus/X