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Bishoy M. Faltas: Extrachromosomal DNA in an independent cohort of 595 urothelial cancer whole genomes

Bishoy Faltas/eipm.weill.cornell.edu

Mar 18, 2025, 06:37

Bishoy M. Faltas: Extrachromosomal DNA in an independent cohort of 595 urothelial cancer whole genomes

Bishoy M. Faltas, Chief Research Officer at the Englander Institute for Precision Medicine and an Associate Professor of Medicine and Cell and Developmental Biology at Weill Cornell Medicine, shared a post on X about recent paper by Wei Lv et al., titled “Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and Tumor-Immune Microenvironment” published on AACR Journals.

Authors: Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Huiying Tao, Yanfen Zhu, Xiaolong Sui, Yue Li, Shiqi Jiang, Qingqing Gao, Elias Rodriguez-Fos, Gino Prasad, Yuanmei Wang, Run Zhou, Zhe Xu, Xiaoguang Pan, Linlin Chen, Xi Xiang, Huajing Teng, Chaoyang Sun, Tianyu Qin, Wei Dong, Yongwei Li, Xun Lan, Xuesong Li, Lin Lin, Lars Bolund, Huanming Yang, Roel G.W. Verhaak, Bishoy M. Faltas, Jacob B. Hansen, Sihan Wu, Paul S. Mischel, Anton G. Henssen, Vineet Bafna, Jens Luebeck, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han

“Excited to be part of this international collaborative effort, now published in AACR Journals! Great to see validation of our findings on extrachromosomal DNA in an independent cohort of 595 urothelial cancer whole genomes:

High prevalence of ecDNA events in UC.
Recurrent CCND1 amplification events within ecDNA forming SVs.

This work further builds on these findings investigating the Spatial-Temporal Diversity of ecDNA:

ecDNA can arise in flat urothelial lesions.
ecDNA is associated with shortened patient survival.
ecDNA is linked to a distinct TIME.
The same tumors can have both clonal and subclonal ecDNA events suggesting ongoing ecDNA biogenesis.
ecDNA can be detected with high specificity from sequencing urinary sediments.”

Bishoy M. Faltas cancer Conghui Li Huiying Tao OncoDaily Oncology Shiqi Jiang urothelial cancer Wei Lv Xiaolong Sui Yanfen Zhu Yuan Liang Yuchen Zeng Yue Li

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