Highlights from IASLC HTTR 2024 by Stephen V Liu

HHTR 2024 took place from December 13-15, 2024, at the Hilton Washington DC National Mall The Wharf.

This meeting brought together experts and professionals to exchange knowledge and foster collaboration.

IASLC’s Hot Topic Meetings in Basic and Translational Science served as a platform for presenting cutting-edge research, addressing challenges in the field, and exploring collaborative opportunities among academic and industrial researchers to advance the understanding and treatment of non-small cell lung cancer (NSCLC).

The conference was co-chaired by Alice Berger, William Lockwood,  Montse Sanchez-Cespedes and Kenichi Suda.

Stephen V Liu is an Associate Professor of Medicine at Georgetown University, where he holds the positions of Director of Thoracic Oncology and Head of Developmental Therapeutics at the Georgetown Lombardi Comprehensive Cancer Center.

As a board-certified medical oncologist specializing in lung cancer and drug development, Dr. Liu is known for his expertise in advanced thoracic malignancies. His research focuses on novel therapeutic agents and innovative combinations to improve treatment outcomes for patients with lung cancer.

Dr. Liu has received multiple teaching awards and actively engages in post-graduate education initiatives. Furthermore, he co-hosts the official podcast of the International Association for the Study of Lung Cancer (IASLC), “Lung Cancer Considered”.

Stephen V Liu shared his insights from IASLC HTTR 2024:

Congratulations to the chairs of the IASLC HTTR24 meeting:

“Congratulations to the chairs of the IASLC HTTR24 meeting – fantastic faculty and content. Engaging. Amazing faculty list. Hope it becomes a regular occurrence! Amazing job by Drs. Will Lockwood, Montse Sanchez-Cespedes Alice Berger and Kenichi Suda!”

An amazing group of trainees and junior faculty:

“Such an amazing group of trainees and junior faculty at the 2024 EGFR Resisters Research Summit. It’s a privilege to hear about all the exciting EGFR work being done. And got to glimpse Louisville will fellow faculty Zosia Piotrowska, Mary Jo Fidler, Helena Yu.”

IASLC friends at the HTTR24 meeting:

“It’s great to see so many IASLC friends in DC at the HTTR24 meeting”

Katerina Politi at IASLC HTTR24:

“Dr. Katerina Politi at IASLC HTTR24 discusses use of in vivo models to study drug resistance and tolerance. Intriguing work on EGFR resistance and SMARCA4, SWI/SNF, even ASCL1.”

Discussion of clonal dynamics by Aaron Hata:

“Brilliant discussion of clonal dynamics with regard to resistance to targeted therapies by Dr. Aaron Hata at the IASLC HTTR24 meeting. Clones can pre-exist and also evolve. Different scenarios likely for early vs late progression.”

Ming-Sound Tsao discusses the role of patient derived xenografts:

“Dr. Ming-Sound Tsao discusses the role of patient derived xenografts (PDX) to study drug resistance at the IASLC HTTR24 meeting. Some advantages over cell lines but also some challenges. Will this help us understand drug tolerant persister populations?”

Ben Neel on resistance and identification of synthetic lethal targets in KRAS STK11 mutant NSCLC:

“Fascinating work on resistance and identification of synthetic lethal targets in KRAS STK11 mutant NSCLC from Benjamin Neel at the IASLC HTTR24 meeting. Understanding the pathways and complexes responsible for resistance will continue to have major translational impact.”

Great posters at HTTR24 from Paul Stockhammer and Brinda Gupta:

“Great posters at HTTR24 from fellows Drs. Paul Stockhammer and Brinda Gupta exploring aspects of EGFR NSCLC resistance such as role of tumor suppressors and the expression of SEZ6 in SCLC transformation. And both are alumni of the EGFR Summit!”

Miriam Molina Arcas on preclinical models of oncogenic KRAS and tumor immunity:

“Dr. Miriam Molina Arcas highlights preclinical models of oncogenic KRAS and tumor immunity at the IASLC HTTR24 meeting, explaining why some models are representative and some are not. KRAS inhibition increases immune inflammation – in specific models…”