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From Periphery to Center stage: 50 years of Advancements in innate Immunity, suggested by Sendurai Mani

Sendurai Mani/LinkedIn

Nov 11, 2024, 23:56

From Periphery to Center stage: 50 years of Advancements in innate Immunity, suggested by Sendurai Mani

Sendurai Mani, Professor of Medicine specializing in Cancer Biology at Brown University, shared a recent article on LinkedIn:

“From Periphery to Center stage: 50 years of Advancements in innate Immunity.

Adaptive immune cells are highly specialized, while innate immunity serves as the body’s first line of defense. Historically, however, innate immunity has been largely overlooked.

In this review, Susan Carpenter and Luke A.J. O’Neil highlight key discoveries that have elevated innate immunity to a central role in immunology, positioning it alongside adaptive immunity as a vital area of study. Today, scientists recognize that innate immunity is essential not only for defense but also for maintaining internal balance and enhancing our understanding of diseases. As we enter this new era, therapies targeting innate immune receptors and pathways offer exciting potential for treating infections, inflammatory diseases, and even cancer.”

Title: From periphery to center stage: 50 years of advancements in innate immunity

Authors: Susan Carpenter and Luke A.J. O’Neill

Periphery to Center stage

Sendurai A. Mani is an Indian-American oncologist and molecular biologist. Currently holding the Dean’s Chair for Translational Oncology at Brown University Warren Alpert Medical School, Dr. Mani also serves as the Associate Director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School. Dr. Mani’s research focuses on finding the mechanisms driving cancer metastasis and therapy resistance, particularly in breast cancer. He is renowned for his discovery of cancer stem cells and their role in tumor progression and treatment resistance.

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