The Warburg effect and how cancer metabolism affects chemotherapy response

Yüksel Ürün shared on X:

“The Warburg effect drives cancer cells to metabolize glucose anaerobically, leading to lactate accumulation.

This lactate drives a process that helps cancer cells repair DNA and resist chemotherapy. By reducing lactate, we can make cancer cells more sensitive to treatment.”

‘NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance‘

Authors: Hengxing Chen, Yun Li, Huafu Li, Xiancong Chen, Huafeng Fu, Deli Mao, Wei Chen, Linxiang Lan, Chunming Wang, Kaishun Hu, Jia Li, Chengming Zhu, Ian Evans, Eddie Cheung, Daning Lu, Yulong He, Axel Behrens, Dong Yin, Changhua Zhang

Source: Yüksel Ürün/X