TIP60 and chemoresistance in cancer cells exposed to DNA damaging agent

Andrew Deans, Associate Director at St Vincent’s Institute of Medical Research, shared a paper by Hengxing Chen, et al. on X:

“TIP60 acts as an ATM-dependent lysine lactylation transferase.

NBS1 lactylation at K388 on the NBS1-MRE11 interaction interface promotes DNA repair and chemoresistance in cancer cells exposed to DNA damaging agents.”

Source: Andrew Deans/X

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.

Authors: Hengxing Chen, Yun Li, Huafu Li, Xiancong Chen, Huafeng Fu, Deli Mao, Wei Chen, Linxiang Lan, Chunming Wang, Kaishun Hu, Jia Li, Chengming Zhu, Ian Evans, Eddie Cheung, Daning Lu, Yulong He, Axel Behrens, Dong Yin and Changhua Zhang.