Kefah Mokbel: Insights into the management of Leptomeningeal Disease and clinical outcomes

Kefah Mokbel, Chair of The Multidisciplinary Breast Cancer Program at London Breast Institute, shared on LinkedIn:

“Insights into the management of Leptomeningeal disease (LMD) and clinical outcomes:

I would like to add the following comments:

In ER-positive breast cancer, Abemaciclib should be considered the CDK4/6 inhibitor of choice due to its superior penetration through the blood-brain barrier (BBB).

Intrathecal therapy remains underutilized in both research and clinical management settings.

Lumbar puncture for direct genomics analysis is also underutilized and warrants further exploration.

The role of PD-1 and PD-L1 inhibitors in patients with PD-L1 positive disease deserves further discussion (response rates exceeds 30%).”

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Source: Kefah Mokbel/LinkedIn