Ed Esplin Highlights Single-Cell Mapping of Early Colorectal Cancer
Ed Esplin, Clinical Geneticist and Medical Officer of Invitae, shared a post on X about a paper by Tuhin K Guha et al. published on BioRxiov:
“Single-cell spatial mapping reveals alteration of tissue microenvironment (TME) during early colorectal cancer.
Our data reveal FAP colonic mucosa, pre-cancer polyps and colorectal cancers exhibit substantial alterations in cell composition and TME, including increased cancer-associated fibroblasts (CAFs), inhibition of tumor infiltrated lymphocytes and cell-adhesion protein by CAFs, the transformation of memory T cells into regulatory T cells, nuclear translocation of beta-catenin from the cell membrane….”
Title: Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer
Authors: Tuhin K Guha, Edward D Esplin, Aaron M Horning, Roxanne Chiu, Kristina Paul, Annika K Weimer, Winston R Becker, Rozelle Laquindanum, Meredith A Mills, D Glen Esplin, Jeanne Shen, Emma Monte, Shannon White, Thomas V Karathanos, Daniel Cotter, Joanna Bi, Uri Ladabaum, Teri A Longacre, Christina Curtis, William J Greenleaf, James M Ford, Michael P Snyder
Read the full article.
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