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Ahmed Kotb: First Line Management of Stage III-IV DLBCL
Photo: Depositphotos
Aug 6, 2025, 08:52

Ahmed Kotb: First Line Management of Stage III-IV DLBCL

Ahmed Kotb, Adult Hematology and Bone Marrow Transplant Specialist at King Faisal Specialist Hospital International Holding Company, shared a post on X:

“ESMO 2025 – Stage III-IV DLBCL

PET+ test MYC ± BCL2

<80, fit:

  • IPI <2 → 6x R-CHOP
  • IPI ≥2 → 6x R-Pola-CHP

≥80 or unfit:

  • Fit: R-miniCHOP
  • Unfit: R-COMP / R-GCVP / R-CEOP

Consider ISRT for bulky/residual and CNS ppx if high-risk.”

Ahmed Kotb: First Line Management of Stage III-IV DLBCL

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