Insight

Jul 11, 2025, 18:59

Mario Balsa: New Nature Study on Lung Cancer in Never Smokers Reveals Key Mutational Forces

Mario Balsa, Medical Oncology Resident at Catalan Institute of Oncology (ICO), shared a post on X about a recent paper by Marcos Díaz-Gay et al. published in Nature:

“New Nature study on lung cancer in never smokers (LCINS) reveals key mutational forces:

Air pollution (not secondhand smoke) is the main driver
EGFR (East Asia) | KRAS (NA/EU) | SBS40a dominant

In lung cancer’s silent subtype, it’s the environment that speaks loudest.”

Lung Cancer

Title: The mutagenic forces shaping the genomes of lung cancer in never smokers

Journal: Nature

Authors: Marcos Díaz-Gay, Tongwu Zhang, Phuc H. Hoang, Charles Leduc, Marina K. Baine, William D. Travis, Lynette M. Sholl, Philippe Joubert, Azhar Khandekar, Wei Zhao, Christopher D. Steele, Burçak Otlu, Shuvro P. Nandi, Raviteja Vangara, Erik N. Bergstrom, Mariya Kazachkova, Oriol Pich, Charles Swanton, Chao Agnes Hsiung, I-Shou Chang, Maria Pik Wong, Kin Chung Leung, Jian Sang, John P. McElderry, Caleb Hartman, Frank J. Colón-Matos, Mona Miraftab, Monjoy Saha, Olivia W. Lee, Kristine M. Jones, Pilar Gallego-García, Yang Yang, Xiaoming Zhong, Eric S. Edell, Jacobo Martínez Santamaría, Matthew B. Schabath, Sai S. Yendamuri, Marta Manczuk, Jolanta Lissowska, Beata Świątkowska, Anush Mukeria, Oxana Shangina, David Zaridze, Ivana Holcatova, Dana Mates, Sasa Milosavljevic, Millica Kontic, Yohan Bossé, Bonnie E. Gould Rothberg, David C. Christiani, Valerie Gaborieau, Paul Brennan, Geoffrey Liu, Paul Hofman, Lixing Yang, Martin A. Nowak, Jianxin Shi, Nathaniel Rothman, David C. Wedge, Robert Homer, Soo-Ryum Yang, Angela C. Pesatori, Dario Consonni, Qing Lan, Bin Zhu, Stephen J. Chanock, Jiyeon Choi, Ludmil B. Alexandrov, Maria Teresa Landi

Read the full article.

Lung Cancer

More posts featuring Mario Balsa on OncoDaily.

air pollution Angela C. Pesatori Anush Mukeria Azhar Khandekar Beata Świątkowska Bin Zhu Bonnie E. Gould Rothberg Burçak Otlu Caleb Hartman cancer Chao Agnes Hsiung Charles Leduc Charles Swanton Christopher D. Steele Dana Mates Dario Consonni David C. Christiani David C. Wedge David Zaridze Eric S. Edell Erik N. Bergstrom Frank J. Colón-Matos Geoffrey Liu I-Shou Chang Ivana Holcatova Jacobo Martínez Santamaría Jian Sang Jianxin Shi Jiyeon Choi John P. McElderry Jolanta Lissowska Kin Chung Leung Kristine M. Jones LCINS Lixing Yang Ludmil B. Alexandrov Lung cancer in never-smokers Lynette M. Sholl Marcos Díaz-Gay Maria Pik Wong Maria Teresa Landi Marina K. Baine Mario Balsa Mariya Kazachkova Marta Manczuk Martin A. Nowak Matthew B. Schabath Millica Kontic Mona Miraftab Monjoy Saha Nathaniel Rothman Olivia W. Lee OncoDaily Oncology Oriol Pich Oxana Shangina Paul Brennan Paul Hofman Philippe Joubert Phuc H. Hoang Pilar Gallego-García Qing Lan Raviteja Vangara Robert Homer Sai S. Yendamuri Sasa Milosavljevic Shuvro P. Nandi Soo-Ryum Yang Stephen J. Chanock Tongwu Zhang Valerie Gaborieau Wei Zhao William D. Travis Xiaoming Zhong Yang Yang Yohan Bossé

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