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Myeloma Paper of the Day, July 11th, Suggested by Robert Orlowski
Jul 11, 2025, 09:14

Myeloma Paper of the Day, July 11th, Suggested by Robert Orlowski

Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:

“Myeloma Paper of the Day:

BCMA is a highly short-lived protein that undergoes K48-linked polyubiquitylation at plasma membrane, and carfilzomib enhances the efficacy of BCMA-directed CAR T cells against both PI-sensitive and refractory myeloma cells.”

Title: Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens

Authors: Leonie Rieger, Kilian Irlinger, Franziska Füchsl, Marlene Tietje, Anna Purcarea, Nicolas Mathis Barbian, Melanie Faber, Carolin Vogelsang, Lisa Pfeuffer, Sonja Stotz, Oleksandra Karpiuk, Tobias Schulze, Abirami Augsburger, Nadine Glaisner, Verena Konetzki, Sabrina Friedel, Andrej Besse, Lenka Besse, Christoph Driessen, Maike Buchner, Kristina Schwamborn, Katja Steiger, Piero Giansanti, Sebastian Theurich, Johannes M. Waldschmidt, Klaus Martin Kortüm, Michael Hudecek, Hermann Einsele, Marion Högner, Bernhard Kuster, Angela Krackhardt, Judith S. Hecker, Florian Bassermann.

You can read the Full Article in Blood.

Myeloma Paper of the Day, July 11th, Suggested by Robert Orlowski

You can find more posts featuring Robert Orlowski in OncoDaily.

Abirami Augsburger Andrej Besse Angela Krackhardt Anna Purcarea BCMA Bernhard Kuster cancer CAR-T Carolin Vogelsang Christoph Driessen Florian Bassermann Franziska Füchsl Hermann Einsele Johannes M Waldschmidt Judith S. Hecker Katja Steiger Kilian Irlinger Klaus Martin Kortüm Kristina Schwamborn Lenka Besse Leonie Rieger Lisa Pfeuffer Maike Buchner Marion Högner Marlene Tietje Melanie Faber Michael Hudecek Myeloma Myeloma Paper of the Day Nadine Glaisner Nicolas Mathis Barbian Oleksandra Karpiuk OncoDaily Oncology Piero Giansanti Robert Orlowski Sabrina Friedel Sebastian Theurich Sonja Stotz Tobias Schulze Verena Konetzki
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