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Patrick Hwu: How can we help CAR T cells survive longer and fight tumors more effectively?

Patrick Hwu/X

Jun 17, 2025, 05:20

Patrick Hwu: How can we help CAR T cells survive longer and fight tumors more effectively?

Patrick Hwu, President and CEO of the Moffitt Cancer Center, shared a post on LinkedIn:

“How can we help CAR T cells survive longer and fight tumors more effectively?

In this study, Bailey et al. found that deleting the interferon-γ receptor (IFN-γR) in CAR T cells prevents IFN-γ–induced cell death, especially in CD28-based CARs, leading to better and more durable responses.

IFN-γR knockout CAR T cells showed enhanced persistence and memory, and delivered more potent tumor control in both liquid and solid tumor models, even protecting against tumor rechallenge. This approach shows removing IFN-γ signaling can rewire CAR T cells for greater durability and antitumor activity, offering a promising path to improve cell therapy for cancer.”

Title: IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models

Authors: Stefanie R. Bailey, Hana N. Takei, Giulia Escobar, Michael C. Kann, Amanda A. Bouffard, Tamina Kienka, Valentina M. Supper, Alexander Armstrong, Diego Salas-Benito, Merle K. Phillips, Filippo Birocchi, Sonika Vatsa, Harrison Silva, Irene Scarfò, Marc Wehrli, Korneel Grauwet, Eli P. Darnell, Charlotte E. Graham, Mark B. Leick, Felix Korell, Trisha R. Berger, Marcela V. Maus

Read the full study in Science Magazine.

Patrick Hwu

More posts featuring Patrick Hwu on OncoDaily.

Alexander Armstrong Amanda A. Bouffard cancer Charlotte E. Graham Diego Salas-Benito Eli P. Darnell Felix Korell Filippo Birocchi Giulia Escobar Hana N. Takei Harrison Silva Irene Scarfò Korneel Grauwet Marc Wehrli Marcela V. Maus Mark B. Leick Merle K. Phillips Michael C. Kann OncoDaily Oncology Patrick Hwu Sonika Vatsa Stefanie R. Bailey Tamina Kienka Trisha R. Berger Valentina M. Supper

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