Patrick Hwu: Are B cells important to eliminate cancers?
Patrick Hwu, President and CEO of Moffitt Cancer Center, shared a post on LinkedIn about a paper by Ayana Ruffin et al. published in Science Translational Medicine:
“Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.
B cells, which produce antibodies, are important to prevent infections and are now being studied for their role in antitumor immune responses.
In a recent article by Ayana Ruffin et al. dysfunctional (double negative) B cells were found to accumulate in patients with head and neck cancer and were associated with disease progression.
This highlights the potential importance of B cells in antitumor immune responses and may indicate that B cell activation strategies should be studied in cancer patients.”
Authors: Ayana Ruffin, Allison Casey, Sheryl Kunning, Robert Ferris, Tullia Bruno et al.
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