Spatial transcriptomics of Intraductal Papillary Mucinous Neoplasms, review by Anirban Maitra
Anirban Maitra, Director of the Sheikh Ahmed Pancreatic Cancer Research Center, shared a post on X:
“New paper on spatial transcriptomics (using GeoMx and CosMx platforms) of Intraductal Papillary Mucinous Neoplasms (IPMNs), precursor lesions of Pancreatic Cancer by Yasmin Hernandez-Barco & colleagues Mass General News.
This study identifies the transcriptomic features of pancreato-biliary, intestinal, and gastric IPMN subtypes (and in particular, basal versus classical lineage compositions, the proportion of CAF subtypes by histology, and immune admixtures in the tumor microenvironment).
For example, PB IPMNs are mostly basal predominant and have Treg infiltrates, while intestinal IPMNs are mostly classical predominant and have macrophage infiltrates.
This study also investigates repeat expression in IPMN progression (David Ting special) and finds repeat upregulation correlates with progression to high grade dysplasia.
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