Sendurai Mani: The Power of Cancer Chimeras – A New Frontier in Cancer Research
Sendurai Mani, Professor of Medicine specializing in Cancer Biology at Brown University, shared a recent article on LinkedIn:
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More than 80% of all human cancers begin in epithelial cells, known as carcinomas. These epithelial cells are immobile and stick together, forming localized and often benign tumors.
However, some of these cells can acquire mesenchymal traits, which give them the mobility to detach and spread while still retaining their epithelial characteristics.
This hybrid state, where cancer cells exhibit both epithelial and mesenchymal properties, acts like a cancer chimera.
This unique duality makes these cells more aggressive, enabling them to evade the immune system, migrate from the primary tumor, and form life-threatening metastases.
In our recent review article, my team members [Nick Kuburich, Ph.D., Julia Kiselka, Petra den Hollander, Andrew Karam (manilab)] at the Legorreta Cancer Center at Brown University, The Warren Alpert Medical School of Brown University, delve into the critical role of this chimeric state in cancer progression.
These hybrid cancer cells hold the key to understanding metastasis, development of treatment resistance, and tumor relapse, as well as developing innovative therapies to tackle one of the biggest challenges in cancer treatment.”
Authors: Nick A. Kuburich, Julia M. Kiselka, Petra den Hollander, Andrew A. Karam and Sendurai A. Mani
Sendurai A. Mani is an Indian-American oncologist and molecular biologist. Currently holding the Deanβs Chair for Translational Oncology at Brown University Warren Alpert Medical School, Dr. Mani also serves as the Associate Director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School. Dr. Maniβs research focuses on finding the mechanisms driving cancer metastasis and therapy resistance, particularly in breast cancer. He is renowned for his discovery of cancer stem cells and their role in tumor progression and treatment resistance.
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